20-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
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چکیده
Received 10 Sep 2013 | Accepted 17 Feb 2014 | Published 12 Mar 2014 20-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity Sherry Y. Wu1,*, Xianbin Yang2,*, Kshipra M. Gharpure1, Hiroto Hatakeyama1, Martin Egli3, Michael H. McGuire1, Archana S. Nagaraja1, Takahito M. Miyake1, Rajesha Rupaimoole1, Chad V. Pecot4, Morgan Taylor1, Sunila Pradeep1, Malgorzata Sierant5, Cristian Rodriguez-Aguayo6,7, Hyun J. Choi1, Rebecca A. Previs1, Guillermo N. Armaiz-Pena1, Li Huang8, Carlos Martinez9, Tom Hassell9, Cristina Ivan1,7, Vasudha Sehgal10, Richa Singhania11,12, Hee-Dong Han1,7,13, Chang Su1, Ji Hoon Kim10,14, Heather J. Dalton1, Chandra Kovvali1, Khandan Keyomarsi15, Nigel A.J. McMillan11,16, Willem W. Overwijk17, Jinsong Liu18, Ju-Seog Lee10, Keith A. Baggerly19, Gabriel Lopez-Berestein6,7, Prahlad T. Ram10, Barbara Nawrot5 & Anil K. Sood1,7,8
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